研究方向

動(dòng)物新型疫苗研發(fā)

個(gè)人簡(jiǎn)介

        何玉龍，博士，副教授，2003年畢業(yè)于內(nèi)蒙古民族大學(xué)動(dòng)物科技學(xué)院動(dòng)物醫(yī)學(xué)專(zhuān)業(yè)。同年考入西北農(nóng)林科技大學(xué)動(dòng)物醫(yī)學(xué)院攻讀碩士學(xué)位。2005年9月，被西北農(nóng)林科技大學(xué)提前推薦為直博研究生，師從著名動(dòng)物克隆專(zhuān)家張涌教授，博士在讀期間主要從事動(dòng)物克隆及轉(zhuǎn)基因方面的研究；2008.12-2010.09期間以訪(fǎng)問(wèn)學(xué)者身份在美國(guó)德州大學(xué)健康科學(xué)中心(University of Texas health science center at San Antonio)進(jìn)行衰老和細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)方面的研究，2011年6月獲西北農(nóng)林科技大學(xué)發(fā)育生物學(xué)博士學(xué)位。同年7月進(jìn)入寧夏大學(xué)西部特色生物資源保護(hù)與利用教育部重點(diǎn)實(shí)驗(yàn)室工作，2012年9月榮獲寧夏回族自治區(qū)“全職引進(jìn)優(yōu)秀博士”稱(chēng)號(hào)。2014年9月晉升為副教授，2015年6月評(píng)為碩士研究生導(dǎo)師。2016年3月調(diào)入浙江理工大學(xué)生命科學(xué)與醫(yī)藥學(xué)院工作。累積發(fā)表學(xué)術(shù)論文40余篇，其中以包括以第一作者或通訊作者在Ageing Research Reviews(醫(yī)學(xué)1區(qū)TOP期刊)、Molecular biology reports、Theriogenology、Research in Veterinary Science、International Journal of Molecular Sciences、Protein & Peptide Letters、Stem Cell Research & Therapy和International Journal of Molecular Medicine等SCI收錄期刊發(fā)表學(xué)術(shù)論文10余篇。主持結(jié)題國(guó)家自然科學(xué)基金項(xiàng)目1項(xiàng)(項(xiàng)目編號(hào)：31460585)、浙江省公益技術(shù)應(yīng)用研究項(xiàng)目1項(xiàng)(項(xiàng)目編號(hào)：2017C32049)、寧夏自治區(qū)自然科學(xué)基金項(xiàng)目1項(xiàng)(項(xiàng)目編號(hào)：NZ12105)，寧夏自治區(qū)留學(xué)回國(guó)人員創(chuàng)新創(chuàng)業(yè)項(xiàng)目1項(xiàng)(批準(zhǔn)文號(hào)：寧人社函〔2014〕486號(hào))及企業(yè)委托橫向課題3項(xiàng)。另外，以主要參加人或?qū)W術(shù)骨干參加國(guó)家“973”計(jì)劃項(xiàng)目子課題(項(xiàng)目編號(hào)：2012CB518801)和“973”前期研究專(zhuān)項(xiàng)各1項(xiàng)(項(xiàng)目編號(hào)：2012CB126301)、國(guó)家自然科學(xué)基金5項(xiàng)(項(xiàng)目編號(hào)分別為：31201867、31260624、31260035、31460039和31472191)。主講本科生《免疫學(xué)》、《生物制品學(xué)》和《生物制藥工藝學(xué)》等多門(mén)課程。參與編寫(xiě)高等教育出版社出版的《免疫學(xué)原理與技術(shù)》教材1部。

成果（與產(chǎn)業(yè)轉(zhuǎn)化相關(guān)為主）

1、Yulong He, Yuehong Wu, Anuja Mishra, Victor Acha, Thomas Andrews, Peter J. Hornsby. Biosensor technology in aging research and age-related diseases. Ageing Research Reviews. 2012,11(1):1-9(醫(yī)學(xué)一區(qū)，IF=10.39)(SCI)

2、Yulong He, Yuehong Wu, Zhigang Lan, Yonggang Liu, Yong Zhang. Molecular analysis of the first intron in the bovine myostatin gene, Molecular biology reports. 2011,38(7):4643-9. ((SCI)

3. Yulong He, Yuehong Wu, Xiaoning He, Fengjun Liu, Xiaoying He, Yong Zhang. An immortalized goat mammary epithelial cell line induced with human telomerase reverse transcriptase (hTERT) gene transfer, Theriogenology. 2009,71(9):1417-24.（SCI）

4. Yulong He, Yuehong Wu, Fusheng Quan, Yonggang Liu, Yong Zhang. Comparative analysis of sequence of myostatin gene and promoter in Qinchuan and Red Angus cattle. Genetics and Molecular Research. 2013,12(3):3398-3406. (SCI)

5. Yuehong Wu, Jianhong Shu, Chengwen He, Min Li, Yujiong Wang, Wenbin Ou, Yulong He(通訊作者). ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset iPS cells by suppressing expression and activity of Caspase-3. Theriogenology. 2016, 85(2):302-314. (SCI)

6. Danping Hong, Jiongyan Ding, Ouyang Li, Quan He, Minxia Ke, Mengyi Zhu, Lili Liu, Wen-Bin Ou, Yulong He(通訊作者) and Yuehong Wu. Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection. Stem Cell Research & Therapy, 2018, 9(1):49. (SCI)

7. Minxia Ke, Quan He, Danping Hong, Ouyang Li, Mengyi  Zhu, Wen?Bin Ou, Yulong He(通訊作者) , Yuehong Wu. Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/?Akt?dependent Tbx?3 activation pathway. International Journal of  Molecular Medicine, 2018, 42(1):131-140. (SCI)

8. Yi Yang, Xiaokang Liu, Ting Wu, Wenping Zhang, Jianhong Shu, Yulong He(通訊作者), Shao-Jun Tang.  Quercetin attenuates AZT-induced neuroinflammation in the CNS. Scientific Reports, 2018, 8(1):6194. (SCI)

9. Yu Tao, Jianhong Shu, Jian Chen, Yuehong Wu, Yulong He(通訊作者). A concise review of vaccines against Mycoplasma hyopneumoniae. Research in Veterinary Science, 2019,123:144-152. (SCI)

10. Rui Yang, Yu Tao, Gaojian Li, Jian Chen, Jianhong Shu and Yulong He(通訊作者). Immunoenhancement of recombinant Neisseria meningitides PorB protein on porcine circovirus type 2 and Mycoplasma hyopneumoniae genetically engineered vaccines. Protein & Peptide Letters, 2019, 26(10): 776 - 784.

11. Yu Tao, Gaojian Li, Wenqian Zheng, Jianhong Shu, Jian Chen, Fang Yang, Yuehong Wu, and Yulong He(通訊作者). Development of a Combined Genetic Engineering Vaccine for Porcine Circovirus Type 2 and Mycoplasma Hyopneumoniae by a Baculovirus Expression System. International Journal of Molecular Sciences. 2019, 20, 4425.

發(fā)明專(zhuān)利

1. 何玉龍, 陶宇, 舒建洪, 陳健, 吳月紅, 楊芳. 豬支原體肺炎和豬圓環(huán)病毒2型重組蛋白及制備二聯(lián)疫苗. 申請(qǐng)?zhí)枺?01811179696.3.

2. 何玉龍, 陶宇, 舒建洪, 陳健, 楊芳, 童夏霞, 盛敏成. 豬支原體肺炎和豬圓環(huán)病毒二聯(lián)基因工程疫苗制備方法. 申請(qǐng)?zhí)枺?01910200702.7.

在研產(chǎn)品

1、豬圓環(huán)病毒2型與豬支原體肺炎二聯(lián)疫苗的研制；

2、分子佐劑的開(kāi)發(fā)。